Skin aging reversed at biological level, study finds

A 2026 clinical study in Dermatology and Therapy reports that skin aging can be reversed at the epigenetic level. The research identifies DNA methylation patterns as a key driver of age-related genetic changes in skin, and confirms this aging process is consistent across diverse ethnic groups, regardless of differences in surface appearance.

The trial involved 60 participants applying topical dihydromyricetin (DHM) for eight weeks. Results demonstrated a decrease in biological skin age, reduced wrinkle visibility, and improvements in skin